Endocrine Abstracts

Cushing’s syndrome is a rare disease with an incidence of 0.72–2.4/million per year. Approximately 14% of patients are over 60 years of age but <1% are over 80 years of age. In a 2-month period, we diagnosed three females over 80 years of age as having Cushing’s syndrome. None of them had a typical cushingoid appearance.Patient 1, 80 years of age. Presentation: coincidental finding of bilateral adrenal hypertrophy on CT scanning as par...

Aim: The aim of this paper is to report on the outcomes of a randomized controlled trial designed to evaluate the effectiveness of a group-based lifestyle intervention programme for reducing the risk factors associated with diabetes in women with pre diabetes following gestational diabetes. We expected that the group based intervention through its educational and supportive approach would enable improvements in psychosocial health, health behaviours, anthropometry, and glucose...

Associations of Insulin-like growth factor-II with cardiovascular risk have been inadequately studied. We studied longitudinal associations of IGF-II with cardiovascular risk factors in people with type 2 diabetes. Subjects and methods: 462 type-2 diabetes patients aged 26 to 86 years from the Salford Diabetes cohort were analysed. Longitudinal clinical information was extracted (years 2002–2009) from an integrated database of primary care and hospital data. IGF-II was me...

Insulin-like growth factors have fundamental roles in metabolism and apoptosis. Circulating IGF-I and IGF-II are primarily sequestrated with IGFBP-3 in ternary complexes with the acid-labile subunit. We hypothesized that polymorphisms of the IGFBP3 gene may impact circulating IGF-II concentrations.Methods: 478 Caucasian patients were selected from the Salford Diabetes Cohort for analysis. Thirteen haplotype tagging single nucleotide polymorphisms (SNPs) ...

Background: Bariatric surgery (BS) results in metabolic pathway recalibration. When major metabolic change occurs, blood protein components have a key role and can be altered significantly. We set out to identify potential biomarkers of change in plasma following BS in people achieving remission of type 2 diabetes mellitus (T2DM).Methods: Longitudinal analysis was performed on serum samples from 10 individuals who all achieved remission of T2DM following...

Aims: We used sequential window acquisition of all theoretical fragment ion spectra Mass Spectrometry (SWATH-MS) to identify proteins acting as markers of remission of type 2 diabetes (T2DM) in patients who lost weight after bariatric surgery.Background: Bariatric surgery results in remission of T2DM in up to 80% of patients. The mechanisms underpinning are largely unknown. N-acetylmuramoyl-L-alanine amidase (PGLRYP2) is an immune response enzyme that br...

Significant knowledge gaps exist regarding the humanistic effects of hypoparathyroidism, a rare, debilitating disorder. We report results from a global survey to characterise the burden of hypoparathyroidism from the patient perspective. An anonymous survey was conducted in patients with uncontrolled chronic hypoparathyroidism (as determined by patients’ report of persistent symptoms and/or poorly controlled calcium levels as told by their physician) despite receiving con...